Dyskinesias may arise:
-At the beginning and end of the drug Generic Eldepryl; usually a choreic hyperkinesis with elements of dystonia and ballizma, mainly involving the lower extremities. Often this type of dyskinesia is accompanied by the phenomenon of 'on-off ";
-At the peak of the dose of levodopa, most often choreic hyperkinesis;
, Against the background of the termination of another dose of Eldepryl; often a painful dystonia involving the distal extremities or trunk muscles and manifested locally painful muscle tension.
In some cases, dyskinesias occur regardless of the phase of the drug levodopa.
Motor fluctuations are often accompanied by severe autonomic and also psychopathology shifts (so-called non-motorized fluctuations). For example, during the termination of another dose of Eldepryl 5mg patient can dramatically increase anxiety (until the development of panic attacks), appear depressed mood, confusion, expressed pain and the duration of the dose - elated state. To correct for fluctuations in the motor initially resorted to an increase in the multiplicity of the drug (but not more than 5 times a day), respectively, reducing its single dose. With the ineffectiveness of this technique consistently add other medications: dopamine agonists, selegiline, COMT inhibitors.
